Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment.

Abstract excerpt

The role of mitochondrial dysfunction as a possible cause of parkinsonism became apparent in the mid-1980s with the discovery of a group of individuals with chronic parkinsonism who had been exposed to the chemical 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the subsequent elucidation of the mode of action of this toxin as a mitochondrial complex I inhibitor. Thereafter, a defect in mitochondrial...

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