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Article

Developing Rat Lung Has a Sided Pacemaker Region for Morphogenesis-Related Airway Peristalsis

2 Dec 2004

Abstract excerpt

Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FGF-10), and appears coupled to lung growth. Airway...

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Identifiers

PMID: 15576668
DOI: 10.1165/rcmb.2004-0304oc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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