Article
Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung.
American journal of respiratory cell and molecular biology - 1 Sept 2008
Gonzaga Sílvia, Henriques-Coelho Tiago, Davey Marcus, Zoltick Philip W, Leite-Moreira Adelino F, Correia-Pinto Jorge, Flake Alan W
Abstract excerpt
Fibroblast growth factor-10 (FGF10) is a mesenchymal growth factor, involved in epithelial and mesenchymal interactions during lung branching morphogenesis. In the present work, FGF10 overexpression was transiently induced in a temporally and spatially restricted manner, during the pseudoglandular or canalicular stages of rat lung development, by trans-uterine ultrasound-guided intraparenchymal microinjections of...
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