Article
Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix.
Science advances - 20 Dec 2024
Hansen Christopher J, Rogers Jackson H, Brown Alexus J, Boatwright Naoko, Siricilla Shajila, O'Brien Christine M, Panja Sourav, Nichols Cameron M, Devanathan Kanchana, Hardy Benjamin M, Does Mark D, Anderson Adam W, Paria Bibhash C, Mahadevan-Jansen Anita, Reese Jeff, Herington Jennifer L
Abstract excerpt
The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in...
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