Article
Cell cycle-mediated regulation of smooth muscle alpha-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors.
The Journal of biological chemistry - 18 Feb 2005
Wang Shu-Xia, Elder Paula K, Zheng Ye, Strauch Arthur R, Kelm Robert J
Abstract excerpt
Expression of smooth muscle alpha-actin in growth factor-induced myofibroblasts and in differentiated vascular smooth muscle cells is transcriptionally controlled by multiple positive or negative trans-acting factors interacting with distinct cis-elements in the 5'-flanking region of the gene. Because none of the transcriptional regulators reported to date is smooth muscle cell- or myofibroblast-specific per se,...
Topics
- Actins
- Adenovirus E1A Proteins
- Animals
- Cell Cycle
- Cell Line
- E1A-Associated p300 Protein
- Enhancer Elements, Genetic
- Fibroblasts
- Gene Expression Regulation
- Mice
- Muscle, Smooth, Vascular
- Mutation
- Nuclear Proteins