Article
Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
The Journal of biological chemistry - 26 Nov 1999
Albanese C, D'Amico M, Reutens A T, Fu M, Watanabe G, Lee R J, Kitsis R N, Henglein B, Avantaggiati M, Somasundaram K, Thimmapaya B, Pestell R G
Abstract excerpt
The adenovirus E1A protein interferes with regulators of apoptosis and growth by physically interacting with cell cycle regulatory proteins including the retinoblastoma tumor suppressor protein and the coactivator proteins p300/CBP (where CBP is the CREB-binding protein). The p300/CBP proteins occupy a pivotal role in regulating mitogenic signaling and apoptosis. The mechanisms by which cell cycle control genes...
Topics
- Adenovirus E1A Proteins
- Animals
- Apoptosis
- Binding Sites
- COS Cells
- CREB-Binding Protein
- Cell Line
- Cyclin D1
- DNA
- E1A-Associated p300 Protein
- Gene Expression Regulation