Article
Protocadherin γC4 regulates neuronal survival and dendritic self-avoidance.
Communications biology - 7 Mar 2026
Higuchi Ryuon, Tatara Masaki, Horino Satoko, Katori Shota, Sanbo Makoto, Hirabayashi Masumi, Watanabe Masahiko, Konno Ayumu, Hirai Hirokazu, Yoshioka Yoshichika, Hirabayashi Takahiro, Kobayashi Toshihiro, Kaneko Ryosuke, Yagi Takeshi
Abstract excerpt
Animal models are indispensable for linking human genetic findings to disease mechanisms. Mutations in protocadherin gamma C4 (γC4), one of the 22 isoforms encoded by the protocadherin-γ (Pcdh-γ) gene cluster, cause a human neurodevelopmental syndrome with progressive microcephaly, seizures, and intellectual disability. Here, we established a γC4 mutant mouse model that exhibits motor dysfunction, seizures,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.