Article
Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells.
The Journal of biological chemistry - 13 Oct 2006
Kaneko Ryosuke, Kato Hiroyuki, Kawamura Yoshimi, Esumi Shigeyuki, Hirayama Teruyoshi, Hirabayashi Takahiro, Yagi Takeshi
Abstract excerpt
The molecular basis for providing the identity and diversity of single neurons is a key for realizing the brain system. Diverse protocadherin isoforms encoded by the Pcdh-alpha and Pcdh-gamma gene clusters are expressed in all of the vertebrates studied. For the Pcdh-alpha isoforms, differential expression patterns have been found in single Purkinje cells by unusual monoallelic and combinatorial types of gene...
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