Article
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Molecular cell - 3 Dec 2004
Riballo Enriqueta, Kühne Martin, Rief Nicole, Doherty Aidan, Smith Graeme C M, Recio María-José, Reis Caroline, Dahm Kirsten, Fricke Andreas, Krempler Andrea, Parker Antony R, Jackson Stephen P, Gennery Andrew, Jeggo Penny A, Löbrich Markus
Abstract excerpt
The hereditary disorder ataxia telangiectasia (A-T) is associated with striking cellular radiosensitivity that cannot be attributed to the characterized cell cycle checkpoint defects. By epistasis analysis, we show that ataxia telangiectasia mutated protein (ATM) and Artemis, the protein defective in patients with RS-SCID, function in a common double-strand break (DSB) repair pathway that also requires H2AX,...
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