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Article

Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.

Mutation research - 3 Feb 2007

Darroudi Firouz, Wiegant Wouter, Meijers Matty, Friedl Anna A, van der Burg Mirjam, Fomina Janna, van Dongen Jacques J M, van Gent Dik C, Zdzienicka Małgorzata Z

Abstract excerpt

We analyzed the phenotype of cells derived from SCID patients with different mutations in the Artemis gene. Using clonogenic survival assay an increased sensitivity was found to X-rays (2-3-fold) and bleomycin (2-fold), as well as to etoposide, camptothecin and methylmethane sulphonate (up to 1.5-fold). In contrast, we did not find increased sensitivity to cross-linking agents mitomycin C and cis-platinum. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17169382
DOI: 10.1016/j.mrfmmm.2006.11.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.PMID 17169382Read ↗

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.Semantic proximity Read ↗

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint ResponseSemantic proximity Read ↗

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.Semantic proximity Read ↗

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand BreaksSemantic proximity Read ↗

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progressionSemantic proximity Read ↗

The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.Semantic proximity Read ↗

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis.Semantic proximity Read ↗

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.Semantic proximity Read ↗

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.Semantic proximity Read ↗

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repairSemantic proximity Read ↗

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complexSemantic proximity Read ↗

Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.Semantic proximity Read ↗

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