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Article

Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.

The Journal of experimental medicine - 13 Apr 2009

Huang Ying, Giblin William, Kubec Martina, Westfield Gerwin, St Charles Jordan, Chadde Laurel, Kraftson Stephanie, Sekiguchi JoAnn

Abstract excerpt

Artemis was initially discovered as the gene inactivated in human radiosensitive T(-)B(-) severe combined immunodeficiency, a syndrome characterized by the absence of B and T lymphocytes and cellular hypersensitivity to ionizing radiation. Hypomorphic Artemis alleles have also been identified in...

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Identifiers

PMID: 19349461
DOI: 10.1084/jem.20082396
PMCID: PMC2715118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19349461-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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