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Article

Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.

Nucleic acids research - 1 Aug 2011

Mohapatra Susovan, Kawahara Misako, Khan Imran S, Yannone Steven M, Povirk Lawrence F

Abstract excerpt

Deficiency in Artemis is associated with lack of V(D)J recombination, sensitivity to radiation and radiomimetic drugs, and failure to repair a subset of DNA double-strand breaks (DSBs). Artemis harbors an endonuclease activity that trims both 5'- and 3'-ends of DSBs. To examine whether endonucleolytic trimming of terminally blocked DSBs by Artemis is a biologically relevant function, Artemis-deficient fibroblasts...

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Identifiers

PMID: 21531702
DOI: 10.1093/nar/gkr257
PMCID: PMC3159448

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Related research

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Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.PMID 21531702Read ↗

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.Semantic proximity Read ↗

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joiningSemantic proximity Read ↗

Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.Semantic proximity Read ↗

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.Semantic proximity Read ↗

A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Semantic proximity Read ↗

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint ResponseSemantic proximity Read ↗

Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase.Semantic proximity Read ↗

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.Semantic proximity Read ↗

Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency.Semantic proximity Read ↗

Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene TransferSemantic proximity Read ↗

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progressionSemantic proximity Read ↗

Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.Semantic proximity Read ↗

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