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Article

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint Response

29 Sept 2004

Abstract excerpt

Mutations in Artemis in both humans and mice result in severe combined immunodeficiency due to a defect in V(D)J recombination. In addition, Artemis mutants are radiosensitive and chromosomally unstable, which has been attributed to a defect in nonhomologous end joining (NHEJ). We show here, however, that Artemis-depleted cell extracts are not defective in NHEJ and that Artemis-deficient cells have normal repair...

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Identifiers

PMID: 15456891
DOI: 10.1128/mcb.24.20.9207-9220.2004

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Related research

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Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint ResponsePMID 15456891Read ↗

Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.Semantic proximity Read ↗

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Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repairSemantic proximity Read ↗

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Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.Semantic proximity Read ↗

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