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Article

Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damage

1 Feb 2005

Abstract excerpt

Artemis plays a crucial role in the hairpin-opening step of antigen receptor VDJ gene recombination in the presence of catalytic subunit of deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PKcs). A defect in Artemis causes human radiosensitive-severe combined immunodeficiency. Cells from Artemis-deficient patients and mice display increased chromosomal instability, but the precise function of this factor...

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Identifiers

PMID: 15723659
DOI: 10.1111/j.1349-7006.2005.00019.x

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Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damagePMID 15723659Read ↗

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Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progressionSemantic proximity Read ↗

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repairSemantic proximity Read ↗

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Artemis, a novel guardian of the genome.Semantic proximity Read ↗

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Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.Semantic proximity Read ↗

Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombinationSemantic proximity Read ↗

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.Semantic proximity Read ↗

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