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Article

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.

The Journal of experimental medicine - 3 Mar 2003

Rooney Sean, Alt Frederick W, Lombard David, Whitlow Scott, Eckersdorff Mark, Fleming James, Fugmann Sebastian, Ferguson David O, Schatz David G, Sekiguchi JoAnn

Abstract excerpt

In developing lymphocytes, the recombination activating gene endonuclease cleaves DNA between V, D, or J coding and recombination signal (RS) sequences to form hairpin coding and blunt RS ends, which are fused to form coding and RS joins. Nonhomologous end joining (NHEJ) factors repair DNA double strand breaks including those induced during VDJ recombination. Human radiosensitive severe combined immunodeficiency...

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Identifiers

PMID: 12615897
DOI: 10.1084/jem.20021891
PMCID: PMC2193825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.PMID 12615897Read ↗

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