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Article

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.

Nature - 2 Aug 2001

Tercero J A, Diffley J F

Abstract excerpt

The checkpoint kinase proteins Mec1 and Rad53 are required in the budding yeast, Saccharomyces cerevisiae, to maintain cell viability in the presence of drugs causing damage to DNA or arrest of DNA replication forks. It is thought that they act by inhibiting cell cycle progression, allowing time for DNA repair to take place. Mec1 and Rad53 also slow S phase progression in response to DNA alkylation, although the...

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Identifiers

PMID: 11484057
DOI: 10.1038/35087607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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