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Article

Haplotype and missing data inference in nuclear families.

Genome research - 1 Aug 2004

Lin Shin, Chakravarti Aravinda, Cutler David J

Abstract excerpt

Determining linkage phase from population samples with statistical methods is accurate only within regions of high linkage disequilibrium (LD). Yet, affected individuals in a genetic mapping study, including those involving cases and controls, may share sequences identical-by-descent stretching on the order of 10s to 100s of kilobases, quite possibly over regions of low LD in the population. At the same time,...

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Identifiers

PMID: 15256514
DOI: 10.1101/gr.2204604
PMCID: PMC509272

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