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Article

Nonlocal interactions are responsible for tertiary structure formation in staphylococcal nuclease.

Biophysical journal - 17 Feb 2010

Kato Shingo, Kamikubo Hironari, Hirano Satoshi, Yamazaki Yoichi, Kataoka Mikio

Abstract excerpt

Rapid molecular collapse mediated by nonlocal interactions is believed to be a crucial event for protein folding. To investigate the role of nonlocal interactions in tertiary structure formation, we performed a nonlocal interaction substitution mutation analysis on staphylococcal nuclease (SNase). Y54 and I139 of wild-type (WT) SNase and Delta140-149 were substituted by cysteine to form intramolecular disulfide...

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Identifiers

PMID: 20159164
DOI: 10.1016/j.bpj.2009.10.048
PMCID: PMC2820656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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