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Article

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.

Clinical pharmacology and therapeutics - 1 Jun 2004

Sai Kimie, Saeki Mayumi, Saito Yoshiro, Ozawa Shogo, Katori Noriko, Jinno Hideto, Hasegawa Ryuichi, Kaniwa Nahoko, Sawada Jun-ichi, Komamura Kazuo, Ueno Kazuyuki, Kamakura Shiro, Kitakaze Masafumi, Kitamura Yutaka, Kamatani Naoyuki, Minami Hironobu, Ohtsu Atsushi, Shirao Kuniaki, Yoshida Teruhiko, Saijo Nagahiro

Abstract excerpt

PURPOSE: A comprehensive haplotype analysis of UGT1A1 in the Japanese population was conducted, and the effects of these haplotypes were investigated with respect to UGT1A1-related phenotypic parameters in patients with cancer who received irinotecan. METHODS: The UGT1A1 gene, including the enhancer, the promoter, and all 5 exons and their flanking regions, was sequenced from 195 Japanese subjects. The gene was...

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Identifiers

PMID: 15179405
DOI: 10.1016/j.clpt.2004.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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