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Sonic hedgehog regulates CRH signal transduction in the adult pituitary

30 Nov 2004

Abstract excerpt

Sonic hedgehog (Shh) is a signaling protein that binds to Patched and mediates its effects through Gli transcription factors. Shh is important in regulating survival and growth in both the embryo and the adult. It is known to be involved in pituitary development, but its role in the adult pituitary has not been investigated. Here, we show Shh and Gli1 immunoreactivity in adult human corticotroph cells....

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PMID: 15572433
DOI: 10.1096/fj.04-2138fje

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