Article
Target cells of gamma3-melanocyte-stimulating hormone detected through intracellular Ca2+ responses in immature rat pituitary constitute a fraction of all main pituitary cell types, but mostly express multiple hormone phenotypes at the messenger ribonucleic acid level. Refractoriness to melanocortin-3 receptor blockade in the lacto-somatotroph lineage.
Endocrinology - 1 Oct 1999
Roudbaraki M, Lorsignol A, Langouche L, Callewaert G, Vankelecom H, Denef C
Abstract excerpt
Gamma3-MSH has recently been shown to be a biologically active peptide in the rat anterior pituitary. It induces a sustained rise in intracellular free calcium levels ([Ca2+]i) in a relatively small population of immature pituitary cells. The present study was intended to identify the target cells of this peptide and to discern the signal-transducing melanocortin (MC) receptor. In dispersed pituitary cells from...
Topics
- Animals
- Animals, Newborn
- Calcium
- Cell Line
- Female
- Growth Hormone
- Hormones
- Intracellular Membranes
- Melanocyte-Stimulating Hormones