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Article

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2002

Kovalovsky Damián, Refojo Damián, Liberman Ana Clara, Hochbaum Daniel, Pereda Marcelo Paez, Coso Omar A, Stalla Günter K, Holsboer Florian, Arzt Eduardo

Abstract excerpt

Nur factors are critical for proopiomelanocortin (POMC) induction by CRH in corticotrophs, but the pathways linking CRH to Nur are unknown. In this study we show that in AtT-20 corticotrophs CRH and cAMP induce Nur77 and Nurr1 expression and transcription at the NurRE site by protein kinase A (PKA) and calcium-dependent and -independent mechanisms. Calcium pathways depend on calmodulin kinase II (CAMKII)...

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Source

Identifiers

PMID: 12089357
DOI: 10.1210/mend.16.7.0863

Genes

CRH
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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