Article
Cytokine control of Leishmania infection in the BALB/c mouse: enhancement and inhibition of parasite growth by local administration of IL-2 or IL-4 is species and time dependent.
Parasite immunology - 1 Jan 1992
Lezama-Davila C M, Williams D M, Gallagher G, Alexander J
Abstract excerpt
The therapeutic potential of locally injected interleukin-2 (IL-2) or interleukin-4 (IL-4) was studied in the footpads of Leishmania mexicana or Leishmania major infected BALB/c mice. The disease state was measured both pathologically, by measuring lesion size, and parasitologically, by counting total parasite numbers from infected footpads. IL-2 (0.5 microgram/dose) or IL-4 (0.1 microgram/dose) was administered...
Topics
- Animals
- Disease Models, Animal
- Female
- Foot
- Injections, Intralesional
- Interleukin-2
- Interleukin-4
- Leishmania mexicana
- Leishmania tropica
- Leishmaniasis, Cutaneous
- Male