Article
Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis.
European journal of immunology - 1 Oct 2000
Alexander J, Carter K C, Al-Fasi N, Satoskar A, Brombacher F
Abstract excerpt
It is well established that a fully competent immune response is required for the successful drug treatment of visceral leishmaniasis. However, recent studies have cast some doubt as to which elements of the immune response synergize with chemotherapeutic treatment. The role of the Th2 response and IL-4 in particular during visceral leishmaniasis awaits clarification. We, therefore, examined the effectiveness of...
Topics
- Animals
- Antibodies, Protozoan
- Antimony Sodium Gluconate
- Antiprotozoal Agents
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Immunoglobulin G
- Interferon-gamma
- Interleukin-10
- Interleukin-4
- Leishmania donovani
- Leishmaniasis, Visceral