CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major.

Abstract excerpt

Infection with Leishmania major in BALB/c mice is accompanied by the development of a nonprotective Th2-type response. It has previously been shown that disease progression, and the activation of a Th2-type response, can occur in the absence of CD28 costimulation following the inoculation of high numbers of L. major promastigotes. In this study, we show that in the absence of CD28-B7 interactions, BALB/c mice can...

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