Article
In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance.
Cell cycle (Georgetown, Tex.) - 1 Apr 2006
Legent Kevin, Mas Magali, Dutriaux Annie, Bertrandy Solange, Flagiello Domenico, Delanoue Rénald, Piskur Jure, Silber Joël
Abstract excerpt
In vitro studies have shown that Drosophila melanogaster has a highly efficient single deoxyribonucleoside kinase (dNK) multisubstrate enzyme. dNK is related to the mammalian Thymidine Kinase 2 (TK2) group involved in the nucleotide synthesis salvage pathway. To study the dNK function in vivo, we constructed transgenic Drosophila strains and impaired the nucleotide de novo synthesis pathway, using antifolates...
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