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Article

Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Zhang Nian-Qu, Zhao Lei, Ma Shuai, Gu Ming, Zheng Xin-Yu

Abstract excerpt

OBJECTIVE: Deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) mutants have been reported to exert suicide gene effects in combined gene/chemotherapy of cancer. Here, we aimed to further evaluate the capacity of the mutanted enzyme and its potential for inhibiting cancer cell growth. METHODS: We altered the sequence of the last 10 amino acids of Dm-dNK to perform site-directed mutagenesis and...

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PMID: 22901180
DOI: 10.7314/apjcp.2012.13.5.2121

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