Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.

The Journal of biological chemistry - 15 Feb 2013

Krishnan Shuba, Zhou Xiaoshan, Paredes João A, Kuiper Raoul V, Curbo Sophie, Karlsson Anna

Abstract excerpt

A strategy to reverse the symptoms of thymidine kinase 2 (TK2) deficiency in a mouse model was investigated. The nucleoside kinase from Drosophila melanogaster (Dm-dNK) was expressed in TK2-deficient mice that have been shown to present with a severe phenotype caused by mitochondrial DNA depletion. The Dm-dNK(+/-) transgenic mice were shown to be able to rescue the TK2-deficient mice. The Dm-dNK(+/-)TK2(-/-) mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Mitochondria

Share to Nucleotides

Share to Phosphotransferases

Share to Thymidine Kinase

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23288848
DOI: 10.1074/jbc.M112.437152
PMCID: PMC3576110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.PMID 23288848Read ↗

Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.Semantic proximity Read ↗

In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance.Semantic proximity Read ↗

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiencySemantic proximity Read ↗

Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient miceSemantic proximity Read ↗

Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders.Semantic proximity Read ↗

Synergistic effect of deoxynucleosides and AAV gene therapy for thymidine kinase 2 deficiencySemantic proximity Read ↗

DTYMK is essential for genome integrity and neuronal survival.Semantic proximity Read ↗

Four Deoxynucleoside Kinase Activities from Drosophila melanogaster Are Contained within a Single Monomeric Enzyme, a New Multifunctional Deoxynucleoside KinaseSemantic proximity Read ↗

Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.Semantic proximity Read ↗

Mitochondrial Thymidine Kinase and the Enzymatic Network Regulating Thymidine Triphosphate Pools in Cultured Human CellsSemantic proximity Read ↗

Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.Semantic proximity Read ↗

Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.