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Article

Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2004

Robien Kim, Ulrich Cornelia M, Bigler Jeannette, Yasui Yutaka, Gooley Ted, Bruemmer Barbara, Potter John D, Radich Jerald P

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) directs intracellular folate toward homocysteine metabolism and away from nucleotide synthesis. Two common MTHFR polymorphisms, C677T and A1298C, are associated with reduced enzyme activity. We evaluated the association of these polymorphisms with risk of relapse and bcr-abl mRNA transcript detection among 336 Caucasian patients who underwent allogeneic...

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Share to Folic Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 15569990
DOI: 10.1158/1078-0432.CCR-04-1057

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia.PMID 15569990Read ↗

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