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Article

Methylenetetrahydrofolate reductase C677T genotypes and clinical outcome following hematopoietic cell transplant.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Dec 2007

Azarpira Negar, Ramzi Mani, Aghdaie Mahdokht Hossein, Daraie Masumeh, Geramizadeh Bita

Abstract excerpt

OBJECTIVE: Methotrexate may be used as a prophylactic agent against graft-versus-host disease in hematopoietic cell transplant. The drug exerts its effect on folate metabolism; 5,10-methylenetetrahydrofolate reductase is a critical enzyme involved in this cycle and is related to the toxicity of methotrexate. METHODS: We examined the association of a single nucleotide polymorphism at position 677 in the...

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PMID: 18194124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Methylenetetrahydrofolate reductase C677T genotypes and clinical outcome following hematopoietic cell transplant.PMID 18194124Read ↗

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