Article
Interplay between methylenetetrahydrofolate reductase gene polymorphism 677C-->T and serum folate levels in determining hyperhomocysteinemia in heart transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Dec 2001
Potena L, Grigioni F, Viggiani M, Magnani G, Sorbello S, Falchetti E, Sassi S, Mantovani V, Bacchi-Reggiani L, Magelli C, Branzi A
Abstract excerpt
BACKGROUND: Homocysteine metabolism is often impaired in heart transplant recipients, and increased total homocysteine plasma levels may constitute a risk factor for the development of heart allograft vascular disease. Although 677C-->T transition in methylenetetrahydrofolate reductase (MTHFR) is associated with increased homocysteine levels in the general population, it is unclear whether MTHFR polymorphism...
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