Article
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Sept 2006
Robien Kim, Bigler Jeannette, Yasui Yutaka, Potter John D, Martin Paul, Storb Rainer, Ulrich Cornelia M
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) play key roles in intracellular folate metabolism. Polymorphisms in these enzymes have been shown to modify toxicity of methotrexate (MTX) after hematopoietic cell transplantation. In this study, we evaluated the risk of acute graft-versus-host disease (GVHD) associated with genetic variation in recipient and donor MTHFR and TS genotypes to...
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