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Article

Polymorphism G80A in the reduced folate carrier gene and its relationship to survival and risk of relapse in acute lymphoblastic leukemia.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Oct 2012

Leyva-Vázquez Marco Antonio, Organista-Nava Jorge, Gómez-Gómez Yazmín, Contreras-Quiroz Adriana, Flores-Alfaro Eugenia, Illades-Aguiar Berenice

Abstract excerpt

BACKGROUND: The reduced folate carrier (RFC1) is a major methotrexate transporter whose impaired function was recognized as a frequent mechanism of antifolate resistance. Recently, a G80A polymorphism has been described in the RFC1. This study evaluated the effect of the G80A polymorphism in the RFC1 gene on survival and risk of relapse of acute lymphoblastic leukemia. METHODS AND RESULTS: Seventy patients with...

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Identifiers

PMID: 22914600
DOI: 10.2310/JIM.0b013e31826803c1

Genes

RFC1

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Polymorphism G80A in the reduced folate carrier gene and its relationship to survival and risk of relapse in acute lymphoblastic leukemia.PMID 22914600Read ↗

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