Article
Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype.
International journal of hematology - 1 Jun 2008
Sugimoto Kyoko, Murata Makoto, Onizuka Makoto, Inamoto Yoshihiro, Terakura Seitaro, Kuwatsuka Yachiyo, Oba Taku, Miyamura Koichi, Kodera Yoshihisa, Naoe Tomoki
Abstract excerpt
Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate. In this study, we investigated whether a common single nucleotide polymorphism at position 677 in the donor or recipient's MTHFR gene affects the risk for acute graft-versus-host disease (GVHD) following allogeneic...
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