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Article

GARP regulates the bioavailability and activation of TGFβ.

Molecular biology of the cell - 1 Mar 2012

Wang Rui, Zhu Jianghai, Dong Xianchi, Shi Minlong, Lu Chafen, Springer Timothy A

Abstract excerpt

Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP functions in latent TGFβ activation and the structural basis of coassociation remain unknown. We find that Cys-192 and Cys-331 of GARP disulfide link to the TGFβ1 prodomain and that GARP with C192A and C331A mutations can also...

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Identifiers

PMID: 22278742
DOI: 10.1091/mbc.E11-12-1018
PMCID: PMC3302739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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