Article
A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer.
Journal of cancer research and clinical oncology - 1 Jan 2005
Matsumura Shunji, Oue Naohide, Nakayama Hirofumi, Kitadai Yasuhiko, Yoshida Kazuhiro, Yamaguchi Yoshiyuki, Imai Kazue, Nakachi Kei, Matsusaki Keisuke, Chayama Kazuaki, Yasui Wataru
Abstract excerpt
PURPOSE: Matrix metalloproteinase-9 (MMP-9, gelatinase B) plays a key role in cancer invasion and metastasis by degradating the extracellular matrix (ECM) and basement membrane barriers. A cytosine (C)-thymidine (T) single nucleotide polymorphism (SNP) at position -1562 in the MMP-9 promoter is r...
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