Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer.

Biochemical and biophysical research communications - 19 Nov 2004

Xu Enping, Lai Maode, Lv Bingjian, Xing Xiaoming, Huang Qiong, Xia Xiaoping

Abstract excerpt

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C-->T transition at -1306, which disrupts an Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with T allele. Our study investigated whether the MMP-2 -1306 C-->T polymorphism contributed to the development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Colorectal Neoplasms

Share to Matrix Metalloproteinase 2

Share to Odds Ratio

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sex Factors

Source

Identifiers

PMID: 15485653
DOI: 10.1016/j.bbrc.2004.09.150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer.PMID 15485653Read ↗

Matrix metalloproteinase-2 (-1306 c>t) promoter polymorphism and risk of colorectal cancer in the Saudi population.Semantic proximity Read ↗

Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese.Semantic proximity Read ↗

Matrix metalloproteinase-2 -1306 C>T gene polymorphism is associated with reduced risk of cancer: a meta-analysis.Semantic proximity Read ↗

Role of Matrix Metallopeptidase-2 Genotypes in Taiwanese Patients With Colorectal Cancer.Semantic proximity Read ↗

[The correlation between polymorphisms of matrix metalloproteinase-2 and -9 genes and colorectal cancer of Chinese patients].Semantic proximity Read ↗

Meta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancer.Semantic proximity Read ↗

Associations between single nucleotide polymorphisms of MMP2, VEGF, and HIF1A genes and the risk of developing colorectal cancer.Semantic proximity Read ↗

The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis.Semantic proximity Read ↗

Matrix metalloproteinase (MMP) -2, -7 and -9 promoter polymorphisms in colorectal cancer in ethnic Kashmiri population - A case-control study and a mini review.Semantic proximity Read ↗

Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.Semantic proximity Read ↗

Matrix metalloproteinase-2 C(-1306)T promoter polymorphism and breast cancer risk in the Saudi population.Semantic proximity Read ↗

A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.