Article
Matrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2007
Nasr Hela Ben, Mestiri Souhir, Chahed Karim, Bouaouina Noureddine, Gabbouj Sallouha, Jalbout Majida, Chouchane Lotfi
Abstract excerpt
BACKGROUND: Matrix metalloproteinases (MMPs) are proteolytic enzymes that play important roles in tumor invasion and metastasis by degrading extracellular matrix components. Genetic variations in promoter regions of MMP genes, affecting their expression, have been associated with susceptibility to cancers. The aim of this study was to investigate the susceptibility and prognostic implications of the MMP-1 (-1607)...
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