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Elucidation of MMP-9 expression and association of MMP-9 rs3918242-1562 C/T promoter polymorphism in the progression of cervical cancer.

Cancer genetics - 1 Apr 2026

Poleboyina Pavan Kumar, Pawar Smita C

Abstract excerpt

This study explores the expression of the MMP-9 gene through transcriptomic analysis and quantitative real-time PCR (qRT-PCR), along with the investigation of the promoter polymorphism rs3918242 (C-1562T) using RFLP, confirmed by Sanger sequencing. A total of 200 samples were analyzed, including 100 cervical squamous cell carcinoma tissues and 100 normal control samples. Results revealed a significant...

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Carcinoma, Squamous Cell
Case-Control Studies
Disease Progression
Matrix Metalloproteinase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Sp1 Transcription Factor

Uterine Cervical Neoplasms

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PMID: 41579783
DOI: 10.1016/j.cancergen.2026.01.008

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SP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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