Article
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
PloS one - 1 Jan 2011
O'Leary John C, Dharia Sheetal, Blair Laura J, Brady Sarah, Johnson Amelia G, Peters Melinda, Cheung-Flynn Joyce, Cox Marc B, de Erausquin Gabriel, Weeber Edwin J, Jinwal Umesh K, Dickey Chad A
Abstract excerpt
The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive episodes, increased susceptibility to post-traumatic stress disorder, bipolar disorder, attempt of suicide, and major...
Topics
- Aged, 80 and over
- Animals
- Blotting, Western
- Corticosterone
- Depressive Disorder
- Humans
- Immunohistochemistry
- Maze Learning
- Mice
- Mice, Knockout
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Tacrolimus Binding Proteins