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Article

Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies.

Pharmacogenetics - 1 Nov 2004

Yang Wanling, White Brook, Spicer Eleanor K, Weinstein Benjamin L, Hildebrandt John D

Abstract excerpt

The alpha subunit of the heterotrimeric G protein Gs (Gsalpha) is involved in numerous physiological processes and is a primary determinant of cellular responses to extracellular signals. Genetic variations in the Gsalpha gene may play an important role in complex diseases and drug responses. To characterize the genetic diversity in this locus, we resequenced exons and flanking introns of the gene in 44 genomic...

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Source

Identifiers

PMID: 15564881
DOI: 10.1097/00008571-200411000-00005

Genes

GNAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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