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Article

Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.

Human mutation - 1 Jan 2005

Zellner Christian, Pullinger Clive R, Aouizerat Bradley E, Frost Philip H, Kwok Pui-Yan, Malloy Mary J, Kane John P

Abstract excerpt

HM74 (GPR109B) and the highly homologous gene, HM74A (GPR109A) code for Gi-G protein-coupled orphan receptors that recently have been discovered to be involved in the metabolic effects of niacin. The B vitamin niacin is an important agent used in the treatment of dyslipidemias, but its use is limited by side effects. The novel role of the adjacent HM74 and HM74A genes in the metabolism of niacin may provide new...

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PMID: 15580557
DOI: 10.1002/humu.20121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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