Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.

Human mutation - 1 Jan 2005

Zellner Christian, Pullinger Clive R, Aouizerat Bradley E, Frost Philip H, Kwok Pui-Yan, Malloy Mary J, Kane John P

Abstract excerpt

HM74 (GPR109B) and the highly homologous gene, HM74A (GPR109A) code for Gi-G protein-coupled orphan receptors that recently have been discovered to be involved in the metabolic effects of niacin. The B vitamin niacin is an important agent used in the treatment of dyslipidemias, but its use is lim...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Primers
Share to Genetic Variation
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Share to Receptors, G-Protein-Coupled

Share to Receptors, Nicotinic

Source

Identifiers

PMID: 15580557
DOI: 10.1002/humu.20121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15580557-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.PMID 15580557Read ↗

GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia.Semantic proximity Read ↗

Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies.Semantic proximity Read ↗

Human NPY gene variants in cardiovascular and metabolic diseases.Semantic proximity Read ↗

Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.Semantic proximity Read ↗

Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy.Semantic proximity Read ↗

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2Semantic proximity Read ↗

Natriuretic peptide pharmacogenetics: membrane metallo-endopeptidase (MME): common gene sequence variation, functional characterization and degradation.Semantic proximity Read ↗

GPR39 Splice Variants Versus Antisense Gene LYPD1: Expression and Regulation in Gastrointestinal Tract, Endocrine Pancreas, Liver, and White Adipose TissueSemantic proximity Read ↗

MicroRNAs differentially regulate carbonyl reductase 1 (CBR1) gene expression dependent on the allele status of the common polymorphic variant rs9024.Semantic proximity Read ↗

Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP).Semantic proximity Read ↗

Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.Semantic proximity Read ↗

Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.