Article
SNPs in genes encoding G proteins in pharmacogenetics.
Pharmacogenomics - 1 May 2011
Klenke Stefanie, Siffert Winfried
Abstract excerpt
Heterotrimeric guanine-binding proteins (G proteins) transmit signals from the cell surface to intracellular signal cascades and are involved in various physiological and pathophysiological processes. Polymorphisms in the genes GNB3 (encoding the Gβ3 subunit), GNAS (encoding the Gαs subunit) and GNAQ (encoding the Gαq subunit) have been the primary focus of investigation. Polymorphisms in these genes could be...
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