Article
Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma?
International archives of allergy and immunology - 1 Dec 2004
Jasek Monika, Obojski Andrzej, Mańczak Maria, Wiśniewski Andrzej, Winiarska Beata, Małolepszy Józef, Jutel Marek, Łuszczek Wioleta, Kuśnierczyk Piotr
Abstract excerpt
BACKGROUND: Eosinophils are important components of allergic inflammation. The immunoglobulin A (IgA) Fc receptor (FcalphaRI), encoded by the FCAR gene, is a possible candidate for eosinophil activation at mucosal surfaces, where IgA is abundant. Both elevated cell surface expression of FcalphaRI and increased avidity for IgA were described on eosinophils from allergic subjects. The aim of our study was to...
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