Article
Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma.
Personalized medicine - 1 May 2020
Sajay-Asbaghi Mohammad, Sadeghi-Shabestrai Mahnaz, Monfaredan Amir, Seyfizadeh Narges, Razavi Alireza, Kazemi Tohid
Abstract excerpt
Aim: Siglec-8 is exclusively expressed on mast cells, eosinophils and basophils. Possible association of six siglec-8 single nucleotide polymorphisms (SNPs) with susceptibility to allergic asthma in the Azeri population of Iran was investigated in this study. Materials & methods: A total of 194 patients and 190 normal subjects were enrolled. PCR single strand conformation polymorphism (PCR-SSCP) was used to...
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