Article
Polymorphisms in IL4 and iLARA confer susceptibility to asthma.
Journal of investigational allergology & clinical immunology - 1 Jan 2009
Amirzargar A A, Movahedi M, Rezaei N, Moradi B, Dorkhosh S, Mahloji M, Mahdaviani S A
Abstract excerpt
BACKGROUND: Asthma is a complex disease that is caused by genetic and environmental factors. The production of interleukin (IL)-4, which can influence mast cell responsiveness to immunoglobulin (Ig) E--mediated signaling, could be modified by genetic variants in the IL-4 promoter. OBJECTIVE: To investigate the association between the IL-4 and IL-4RA promoter polymorphisms and asthma in a sample of Iranian...
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