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Article

Polymorphisms in IL4 and iLARA confer susceptibility to asthma.

Journal of investigational allergology & clinical immunology - 1 Jan 2009

Amirzargar A A, Movahedi M, Rezaei N, Moradi B, Dorkhosh S, Mahloji M, Mahdaviani S A

Abstract excerpt

BACKGROUND: Asthma is a complex disease that is caused by genetic and environmental factors. The production of interleukin (IL)-4, which can influence mast cell responsiveness to immunoglobulin (Ig) E--mediated signaling, could be modified by genetic variants in the IL-4 promoter. OBJECTIVE: To investigate the association between the IL-4 and IL-4RA promoter polymorphisms and asthma in a sample of Iranian...

Topics

Asthma
DNA Mutational Analysis
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Immunoglobulin E
Interleukin-4
Interleukin-4 Receptor alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Iran

Polymorphism, Genetic

Promoter Regions, Genetic

Skin Tests

Th2 Cells

Source

Identifiers

PMID: 20128416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20128416-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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