Article
Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Oct 2004
Hytönen A-M, Löwhagen O, Arvidsson M, Balder B, Björk A L, Lindgren S, Hahn-Zoric M, Hanson L A, Padyukov L
Abstract excerpt
BACKGROUND: Development of asthma is likely to depend on a complex interaction between environmental and genetic factors. Several groups have suggested the gene of the IL-4 receptor alpha chain (IL4R) as a candidate gene for the development of asthma, although association with single polymorphisms has shown contradicting results. OBJECTIVE: We chose to analyse IL4R gene haplotypes and assess their possible...
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