Article
Transferrin-a modulates hepcidin expression in zebrafish embryos.
Blood - 19 Mar 2009
Fraenkel Paula G, Gibert Yann, Holzheimer Jason L, Lattanzi Victoria J, Burnett Sarah F, Dooley Kimberly A, Wingert Rebecca A, Zon Leonard I
Abstract excerpt
The iron regulatory hormone hepcidin is transcriptionally up-regulated in response to iron loading, but the mechanisms by which iron levels are sensed are not well understood. Large-scale genetic screens in the zebrafish have resulted in the identification of hypochromic anemia mutants with a ran...
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