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Article

Microsatellite instability in the peripheral blood leukocytes of HNPCC patients.

Human mutation - 1 Mar 2010

Coolbaugh-Murphy Mary I, Xu Jing-Ping, Ramagli Louis S, Ramagli Brian C, Brown Barry W, Lynch Patrick M, Hamilton Stanley R, Frazier Marsha L, Siciliano Michael J

Abstract excerpt

Most hereditary nonpolyposis colorectal cancer (HNPCC) patients inherit a defective allele of a mismatch repair (MMR) gene, usually MLH1 or MSH2, resulting in high levels of microsatellite instability (MSI-H) in the tumors. Presence of MSI in the normal tissues of mutation carriers has been controversial. Here we directly compare MSI in the peripheral blood leukocyte (PBL) DNA of seven HNPCC patients carrying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 20052760
DOI: 10.1002/humu.21190
PMCID: PMC3544178

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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