Article
Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene.
Orthodontics & craniofacial research - 1 Nov 2004
Savontaus M, Rintala-Jämsä M, Morko J, Rönning O, Metsäranta M, Vuorio E
Abstract excerpt
OBJECTIVE: To analyze the effect of a type II collagen mutation on craniofacial development in transgenic Del1 mice. DESIGN: Samples from homozygous (+/+) and heterozygous (+/-) transgenic Del1 mice harboring mutations in the type II collagen gene as well as non-transgenic (-/-) littermates were collected at days 12.5, 14.5, 16.5 and 18.5 of gestation. The cartilaginous and bony elements of the craniofacial...
Topics
- Animals
- Chondrogenesis
- Cleft Palate
- Collagen Type II
- Collagen Type IX
- Collagen Type X
- Craniofacial Abnormalities
- Extracellular Matrix Proteins
- Gene Deletion
- Gestational Age
- Heterozygote
- Homozygote
- Mandible